The last four clashes between the two teams have all been won by the home side on the day, whilst Gloucester's most recent victory at the Stoop was 31-21 in the Premiership on 9 September 2006.
Harlequins only win in their last four matches in all competitions was 19-8 at Newcastle in the LV= Cup. Quins have drawn their last two encounters at the Twickenham Stoop: 9-all against London Irish in the Guinness Premiership and 15-all against Scarlets in the Anglo-Welsh tournament.
Gloucester Rugby's 12-9 victory at home to Leicester on Friday night ended a six game losing run in all competitions. Gloucester's only win on the road in any competition in their last 13 matches was 26-10 at Leeds in the Guinness Premiership on 4 October.
Referee: Tim Wigglesworth (16th Premiership game)
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